Check droppable runes, uniques, sets, and runewords by farming area.
24 Areas
Level 85 area in Act 1. Easy monsters, all items can drop. Great for both rune and item farming.
Level 85 area. No cold immunes, great for Blizzard Sorceress. Lower density than Pit.
Countess has guaranteed rune drops. Hell Countess drops up to Ist (r24). Best for mid-tier runes.
Massive monster density. Best for base item farming. High rune drops from sheer volume of kills.
Always uses enhanced quest drop table. Set/unique rates reduced ~20% in 3.0. Best for SoJ, unique rings, low-mid uniques.
Level 85 area. No cold immunes! Best area for Blizzard Sorceress MF runs.
Level 85 area in Act 2. Less popular but viable for MF runs.
Level 85 area but narrow corridors make it impractical for most builds.
Multiple tombs with decent density. Good for leveling and casual farming.
Ghosts (Wraiths) cannot drop armor/weapons, increasing rune drop chance. Good for mid-high runes.
Drops Key of Hate. Part of Uber key farming rotation. Ghosts have good rune drop tables.
Can be moat-tricked by Sorceress. Drops many high-end uniques. Fast runs with Teleport.
Council members have high TC and can drop up to Zod. Very compact area. Great for Horker Barbarian.
Super chests near campfires. Best method for Sur/Ber rune farming with fast map resets. Offline/single player focused.
High density area with many small monsters. Decent for rune farming through volume.
Level 85 area + Diablo boss kill. Highest elite density. Drops everything. Best overall farming spot.
Level 85 area before Chaos Sanctuary. Can be combined with CS runs.
Quest reward: Normal up to Amn, Nightmare up to Um, Hell up to Gul. One-time per difficulty per character.
Super unique near portal. Fastest MF run possible. Can drop almost everything (except Azurewrath, Tyrael's).
Level 85 area. Very high density but dangerous. All item drops possible. Multiple floors.
Baal waves + Baal kill. Highest TC boss in the game. All items can drop.
Drops Destruction Key. Uses Corpse Explosion, dangerous. Good for key farming.
Two super uniques right next to waypoint. Extremely fast runs. Good for runes and uniques.
Eldritch super unique is right by the waypoint. Quick access for fast runs.